![]() ![]() The durations of Ca 2+ transient clusters (CTCs) correspond to slow wave durations (plateau phase). Ca 2+ transients are clustered within the time course of slow waves but fire asynchronously during these clusters. ![]() Ca 2+ transients in ICC-MY display a complex firing pattern caused by localized Ca 2+ release events arising from multiple sites in cell somata and processes. Here, we characterize the nature of Ca 2+ transients in ICC-MY within intact muscles, using mice expressing a genetically encoded Ca 2+ sensor, GCaMP3, in ICC. Thus, mechanisms of Ca 2+ regulation in ICC are fundamental to the motor patterns of the bowel. Slow waves depend on activation of Ca 2+-activated Cl − channels (ANO1) in ICC, propagate actively within networks of ICC-MY, and conduct to smooth muscle cells where they generate action potentials and phasic contractions. Interstitial cells of Cajal (ICC) in the myenteric plexus region (ICC-MY) of the small intestine are pacemakers that generate rhythmic depolarizations known as slow waves. ![]()
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